Thrombotic thrombocytopenic purpura treated with vincristine in a Jehovah′s witness
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چکیده
منابع مشابه
Thrombotic thrombocytopenic purpura treated with rituximab in systemic lupus erythematosus
*Corresponding author: Mansoor Karimifar, Department of Rheumatology, Isfahan University of Medical Sciences, Isfahan, Iran. E-mail: [email protected] Systemic lupus erythematosus (SLE) is a systemic disease that can lead to involvement of many organs such as bone marrow, blood vessels, skin, heart, kidneys and central nervous system (1). Thrombotic thrombocytopenic purpura (TTP) is c...
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BACKGROUND AND OBJECTIVES Treatment of thrombotic thrombocytopenic purpura (TTP) with plasma exchange has reduced mortality rates from 90% in untreated cases to less than 20%. Despite plasma exchange, relapses may occur in as many as 40% of cases. Multiple relapses occur in a minority but pose a significant therapeutic challenge. Recent evidence supports the presence of an autoantibody which in...
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Thrombotic thrombocytopenic purpura (TTP) is a multisystem disorder characterized by microvascular aggregation of platelets and fibrin strands causing thrombocytopenia, microangiopathic hemolytic anemia, and organ dysfunction. TTP can develop as a result of a deficiency in ADAMTS13 enzyme activity due to either a genetic defect or, more commonly, the development of anti-ADAMTS13 autoantibodies....
متن کاملThrombotic Thrombocytopenic Purpura
Thrombotic microangiopathy comprises a spectrum of clinical and lab findings including microangiopathic hemolytic anemia, thrombocytopenia, and thrombosis of capillary and arterioles. Platelet and hyaline thrombi with complete or partial occlusion of these vessels are integral histopathological findings. These findings are seen irrespective of cause and organ involved. Pathogenesis and prognosi...
متن کاملThrombotic thrombocytopenic purpura.
A 6-year-old boy presented with microangiopathic hemolytic anemia, thrombo-cytopenia, altered sensorium and intractable bleeding. A diagnosis of thrombotic thrombocytopenic purpura was made and the child recovered dramatically after plasmapheresis. Recent developments in the understanding of TTP are reviewed, including the importance of a metaloprotease required to cleave multimers of von Willi...
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ژورنال
عنوان ژورنال: Asian Journal of Transfusion Science
سال: 2011
ISSN: 0973-6247
DOI: 10.4103/0973-6247.83255